Strong emerging rationale for combining oncogene-targeted agents with immunotherapy
نویسندگان
چکیده
In a mastocytoma model expressing mutant c-KIT, a combination of the c-KIT inhibitor dasatinib and an OX40-specific monoclonal antibody synergized in triggering a strong antitumor T-cell response that promoted curative therapeutic effects. Along with a number of other recent studies, these data support the notion that combining targeted agents with immunotherapy may constitute a promising approach for cancer therapy.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013